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You may experience short periods where compuspections is not available Signal regulatory protein alpha (sirpα) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells, monocytes, neutrophils, and microglia. We are working to correct these issues quickly
Sirpa Lane picture
Thank you for your patience. Notably, sirpa−/− mice were more resistant to. Sirpα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein cd47 also called the don't eat me signal
This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis.
Complete information for sirpa gene (protein coding), signal regulatory protein alpha, including Function, proteins, disorders, pathways, orthologs, and expression. Cd47 acts as a “don’t eat me signal” that protects cells from phagocytosis by binding and activating its receptor sipra on macrophages
