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Though pbl is associated with human immunodeficiency virus infection and other immunosuppressed states, it can also affect immunocompetent individuals. Despite significant advances in the field of lymphomas since this subtype was first described in a case series by delecluse et al in 1997, pbl continues to pose challenges with diagnosis and management.[1] patients usually present with extranodal masses involving the oral cavity or the. 2 in the original report by delecluse and colleagues, 1 15 of 16 patients were infected with hiv, 1 was an elderly patient, and all the patients had involvement of.
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Plasmablastic lymphoma is an aggressive large b cell lymphoma with plasmablast / immunoblast morphologic features with plasma cell differentiation usually in association to immunodeficiency In this issue of blood, di ciaccio et al 1 report a unique series of 281 patients, providing more definitive insights into the prognosis of pbl Plasmablastic lymphoma (pbl) is a highly aggressive b cell non‐hodgkin lymphoma frequently associated with immunosuppression, particularly human immunodeficiency virus (hiv) infection
Although pbl is rare globally, south africa has a high burden of.
There is no standard approach to treatment, and the prognosis of pbl has only been assessed through small case series
