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Her2, or erbb2, belongs to the egfr family and is the only member that does not require ligand binding for activation. Human epidermal growth factor receptor 2 (her2) amplification occurs in approximately 5% of metastatic colorectal cancer and it has been studied as a mechanism of resistance for anti. Aflibercept, when combined with fluorouracil, leucovorin, and irinotecan, is fda approved in mcrc that is resistant to or has progressed under a regimen containing oxaliplatin.

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To date, the emergence of several types of targeted drugs has opened new possibilities and revealed new prospects for mcrc treatment Chemotherapy remains as the mainstay of treatment with only few available targeted therapies Therapeutic strategies are continually being updated to select the most suitable targeted drugs based on the results of clinical trials that are currently underway.